Release Research

Turmeric Root

  1. Aggarwal, Bharat B et al. “Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric.” Molecular nutrition & food research Vol. 57,9 (2013): 1529-42. doi:10.1002/mnfr.201200838

  1. Li, Cheng et al. “Curcuminoids: Implication for inflammation and oxidative stress in cardiovascular diseases.” Phytotherapy research : PTR Vol. 33,5 (2019): 1302-1317. doi:10.1002/ptr.6324

  1. Kocaadam, Betül, and Nevin Şanlier. “Curcumin, an active component of turmeric (Curcuma longa), and its effects on health.” Critical reviews in food science and nutrition Vol. 57,13 (2017): 2889-2895. doi:10.1080/10408398.2015.1077195

  1. Gupta, Subash C et al. “Multitargeting by turmeric, the golden spice: From kitchen to clinic.” Molecular nutrition & food research vol. 57,9 (2013): 1510-28. doi:10.1002/mnfr.201100741

  1. Aggarwal, Bharat B, and Kuzhuvelil B Harikumar. “Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.” The international journal of biochemistry & cell biology Vol. 41,1 (2009): 40-59. doi:10.1016/j.biocel.2008.06.010



Glucosamine Sulfate

  1. Bruyère, Olivier et al. “Efficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys.” Seminars in arthritis and rheumatism Vol. 45,4 Suppl (2016): S12-7. doi:10.1016/j.semarthrit.2015.11.011

  1. Henrotin, Yves et al. “What is the current status of chondroitin sulfate and glucosamine for the treatment of knee osteoarthritis?.” Maturitas Vol. 78,3 (2014): 184-7. doi:10.1016/j.maturitas.2014.04.015

  1. Mantovani, Veronica et al. “Chondroitin Sulfate and Glucosamine as Disease Modifying Anti- Osteoarthritis Drugs (DMOADs).” Current medicinal chemistry Vol. 23,11 (2016): 1139-51. doi:10.2174/0929867323666160316123749

  1. Lomonte, Andrea Barranjard Vannucci et al. “Multicenter, randomized, double-blind clinical trial to evaluate efficacy and safety of combined glucosamine sulfate and chondroitin sulfate capsules for treating knee osteoarthritis.” Advances in rheumatology (London, England) vol. 58,1 41. 5 Dec. 2018, doi:10.1186/s42358-018-0041-9

  1. Reginster, Jean-Yves et al. “Role of glucosamine in the treatment for osteoarthritis.” Rheumatology international vol. 32,10 (2012): 2959-67. doi:10.1007/s00296-012-2416-2



Ginger Extract

  1. Kim, Seunghae et al. “Ginger Extract Ameliorates Obesity and Inflammation via Regulating MicroRNA-21/132 Expression and AMPK Activation in White Adipose Tissue.” Nutrients vol. 10,11 1567. 23 Oct. 2018, doi:10.3390/nu10111567

  1. Çifci, Atilla et al. “Ginger ( Zingiber officinale ) prevents severe damage to the lungs due to hyperoxia and inflammation.” Turkish journal of medical sciences vol. 48,4 892-900. 16 Aug. 2018, doi:10.3906/sag-1803-223

  1. Aryaeian, Naheed et al. “The effect of ginger supplementation on some immunity and inflammation intermediate genes expression in patients with active Rheumatoid Arthritis.” Gene vol. 698 (2019): 179-185. doi:10.1016/j.gene.2019.01.048

  1. Mohd Sahardi, Nur Fatin Nabilah, and Suzana Makpol. “Ginger (Zingiber officinale Roscoe) in the Prevention of Ageing and Degenerative Diseases: Review of Current Evidence.” Evidence-based complementary and alternative medicine : eCAM vol. 2019 5054395. 20 Aug. 2019, doi:10.1155/2019/5054395

  1. Cakir, Ufuk et al. “Ginger (Zingiber officinale Roscoe) for the treatment and prevention of necrotizing enterocolitis.” Journal of ethnopharmacology vol. 225 (2018): 297-308. doi:10.1016/j.jep.2018.07.009



Chondroitin Sulfate

  1. Mikami, Tadahisa, and Hiroshi Kitagawa. “Biosynthesis and function of chondroitin sulfate.” Biochimica et biophysica acta vol. 1830,10 (2013): 4719-33. doi:10.1016/j.bbagen.2013.06.006

  1. Reginster, Jean-Yves et al. “Pharmaceutical-grade Chondroitin sulfate is as effective as celecoxib and superior to placebo in symptomatic knee osteoarthritis: the ChONdroitin versus CElecoxib versus Placebo Trial (CONCEPT).” Annals of the rheumatic diseases vol. 76,9 (2017): 1537-1543. doi:10.1136/annrheumdis-2016-210860

  1. Bishnoi, Mamta et al. “Chondroitin sulphate: a focus on osteoarthritis.” Glycoconjugate journal vol. 33,5 (2016): 693-705. doi:10.1007/s10719-016-9665-3

  1. Bruyere, Olivier, and Jean-Yves Reginster. “Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis.” Drugs & aging vol. 24,7 (2007): 573-80. doi:10.2165/00002512-200724070-00005

  1. Clegg, Daniel O et al. “Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis.” The New England journal of medicine vol. 354,8 (2006): 795-808. doi:10.1056/NEJMoa052771



Boswellia Extract

  1. Ranjbarnejad, Tayebeh et al. “Methanolic extract of Boswellia serrata exhibits anti-cancer activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells.” Prostaglandins & other lipid mediators vol. 131 (2017): 1-8. doi:10.1016/j.prostaglandins.2017.05.003

  1. Bannuru, Raveendhara R et al. “Efficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis.” Seminars in arthritis and rheumatism vol. 48,3 (2018): 416-429. doi:10.1016/j.semarthrit.2018.03.001

  1. Umar, Sadiq et al. “Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis.” Phytomedicine : international journal of phytotherapy and phytopharmacology vol. 21,6 (2014): 847-56. doi:10.1016/j.phymed.2014.02.001

  1. Siddiqui, M Z. “Boswellia serrata, a potential antiinflammatory agent: an overview.” Indian journal of pharmaceutical sciences vol. 73,3 (2011): 255-61. doi:10.4103/0250-474X.93507

  1. Kimmatkar, N et al. “Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial.” Phytomedicine : international journal of phytotherapy and phytopharmacology vol. 10,1 (2003): 3-7. doi:10.1078/094471103321648593





MSM (Methylsulfonylmethane)

  1. Butawan, Matthew et al. “Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement.” Nutrients vol. 9,3 290. 16 Mar. 2017, doi:10.3390/nu9030290

  1. Kim, L S et al. “Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial.” Osteoarthritis and cartilage vol. 14,3 (2006): 286-94. doi:10.1016/j.joca.2005.10.003

  1. Miller, Lindsey E. “Methylsulfonylmethane decreases inflammatory response to tumor necrosis factor-α in cardiac cells.” American journal of cardiovascular disease vol. 8,3 31-38. 15 Jun. 2018

  1. Withee, Eric D et al. “Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial.” Journal of the International Society of Sports Nutrition vol. 14 24. 21 Jul. 2017, doi:10.1186/s12970-017-0181-z

  1. Barmaki, S et al. “Effect of methylsulfonylmethane supplementation on exercise - Induced muscle damage and total antioxidant capacity.” The Journal of sports medicine and physical fitness vol. 52,2 (2012): 170-4.



BioPerine

  1. https://www.bioperine.com/index.php/researchhighlight

  1. Peterson, Christine T et al. “Effects of Turmeric and Curcumin Dietary Supplementation on Human Gut Microbiota: A Double-Blind, Randomized, Placebo-Controlled Pilot Study.” Journal of evidence-based integrative medicine vol. 23 (2018): 2515690X18790725. doi:10.1177/2515690X18790725

  1. Vasto, Sonya et al. “Dietary Supplements as Surrogate of Mediterranean Diet in Healthy Smoking Subjects.” Rejuvenation research vol. 21,1 (2018): 37-43. doi:10.1089/rej.2017.1950

  1. https://www.bioperine.com/index.php/mechanismsofactions

Quercetin

  1. Davis, J Mark et al. “Effects of the dietary flavonoid quercetin upon performance and health.” Current sports medicine reports vol. 8,4 (2009): 206-13. doi:10.1249/JSR.0b013e3181ae8959

  1. Li, Yao et al. “Quercetin, Inflammation and Immunity.” Nutrients vol. 8,3 167. 15 Mar. 2016, doi:10.3390/nu8030167

  1. Andres, Susanne et al. “Safety Aspects of the Use of Quercetin as a Dietary Supplement.” Molecular nutrition & food research vol. 62,1 (2018): 10.1002/mnfr.201700447. doi:10.1002/mnfr.201700447

  1. Eid, Hoda M, and Pierre S Haddad. “The Antidiabetic Potential of Quercetin: Underlying Mechanisms.” Current medicinal chemistry vol. 24,4 (2017): 355-364. doi:10.2174/0929867323666160909153707

  1. Marunaka, Yoshinori et al. “Actions of Quercetin, a Polyphenol, on Blood Pressure.” Molecules (Basel, Switzerland) vol. 22,2 209. 29 Jan. 2017, doi:10.3390/molecules22020209



Methionine

  1. Levine, R L et al. “Oxidation of methionine in proteins: roles in antioxidant defense and cellular regulation.” IUBMB life vol. 50,4-5 (2000): 301-7. doi:10.1080/713803735

  1. Stadtman, Earl R et al. “Methionine oxidation and aging.” Biochimica et biophysica acta vol. 1703,2 (2005): 135-40. doi:10.1016/j.bbapap.2004.08.010

  1. Kim, Geumsoo et al. “Methionine oxidation and reduction in proteins.” Biochimica et biophysica acta vol. 1840,2 (2014): 901-5. doi:10.1016/j.bbagen.2013.04.038

  1. Drazic A, Winter J. The physiological role of reversible methionine oxidation. Biochim Biophys Acta. 2014;1844(8):1367–1382. doi:10.1016/j.bbapap.2014.01.001

  1. Hoshi, T, and S Heinemann. “Regulation of cell function by methionine oxidation and reduction.” The Journal of physiology vol. 531,Pt 1 (2001): 1-11. doi:10.1111/j.1469-7793.2001.0001j.x



Bromelain

  1. Rathnavelu, Vidhya et al. “Potential role of bromelain in clinical and therapeutic applications.” Biomedical reports vol. 5,3 (2016): 283-288. doi:10.3892/br.2016.720

  1. de Lencastre Novaes, Letícia Celia et al. “Stability, purification, and applications of bromelain: A review.” Biotechnology progress vol. 32,1 (2016): 5-13. doi:10.1002/btpr.2190

  1. Ramli, Aizi Nor Mazila et al. “Bromelain: from production to commercialisation.” Journal of the science of food and agriculture vol. 97,5 (2017): 1386-1395. doi:10.1002/jsfa.8122

  1. Pavan, Rajendra et al. “Properties and therapeutic application of bromelain: a review.” Biotechnology research international vol. 2012 (2012): 976203. doi:10.1155/2012/976203

  1. Lete, Iñaki et al. “Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study.” European journal of obstetrics, gynecology, and reproductive biology vol. 228 (2018): 221-224. doi:10.1016/j.ejogrb.2018.07.002